Risk factors analysis of type 2 diabetes mellitus combined with hepatic fibrosis

Abstract

Objective To investigate the clinical risk factors of type 2 diabetes mellitus (T2DM)combined with hepatic fibrosis. Methods Totally 112 patients with T2DM from Department of Endocrinology, the First Affiliated Hospital of Xinjiang Medical University from April to September in 2013 were enrolled in our study. Male patients were 69, female patients were 43, age was 53±1, the average of duration of T2DM was 4 year (1- 10 year). They were divided into 2 groups, according to the fibroscan measured, T2DM combined with hepatic fibrosis group (liver hardness value ≥6.65 kPa, group A, case group, n=44); T2DM without hepatic fibrosis (liver hardness value<6.65 kPa, group B, control group, n=68). The gender, age, ethnic, disease history, laboratory examination (liver enzyme)and ultrasound were collected and analyzed with univariate analysis and multivariate analysis. Results (1)Patients of case group had a significantly higher ratio of having hypertension history (52.3%), fatty liver (90.9%), rate of poor blood glucose control (70.5%), body mass index (BMI) ((28.49 ± 0.16)kg/m2), alanine aminotransferase (ALT) (20.04 (14.75-47.40)U/L), aspartate aminotransferase (AST) (26.70 (17.10~36.91)U/L)than those in control group (26.5%, 69.1%, 50.0%, 26.32±0.39, 16.30 (13.63-20.40), 19.25 (14.50-27.68), χ2=7.664, 7.316, 4.589; t=- 3.121, Z=- 2.121, - 2.821; P<0.05 all above). White blood cell count (6.58 ± 0.25), neutrophile count (3.75 ± 0.18), mean corpuscular volume (MCV) (87.51 ± 0.59)in case group were significantly lower than those in control group (7.54±0.25, 4.47±0.19, 89.74±0.49) (t=2.740, 2.789, 2.876; P<0.01 all above) . (2)Multivaiate logistic regression analysis showed that hypertension history, fatty liver, increased AST, decreased white blood cell count and decreased MCV were the independent risk factors of T2DM combined with hepatic fibrosis (OR=3.576, 3.850, 1.110, 0.669, 0.808, P<0.05 all above). Conclusion Hypertension history, fatty liver, increased AST, decreased white blood cell count and decreased MCV were the related risk factors of T2DM combined with hepatic fibrosis. This study provides a theoretical basis to early screen patients with hepatic fibrosis in T2DM. Key words: Diabetes mellitus, type 2; Hepatic fibrosis; Risk factors