Abstract
Background: Atherosclerosis is the main reason of Coronary Artery Disease (CAD). The studies show that several factors are interconnected with the development and progression of CAD including lipid peroxidation, inflammation and homeostasis. The aim of this study was to evaluate the serum level of Oxidized LDL (OX-LDL) and Malondialdehyde (MDA) and their association with the extent of Coronary Artery Disease. Methods: In this cross-sectional study serum OX-LDL and MDA levels were determined in 160 patients with Coronary Artery Disease comprised of 40 subjects with no vessel disease, 40 subjects with single vessel disease, 40 subjects with double vessel disease, and 40 subjects with triple vessel disease matched control healthy 20 subjects. Serum levels of OX-LDL determined used to (ELISA) procedure. Serum level of MDA was measured by photometric method based on reaction with Thiobarbituric Acid (TBA). Data were analyzed using Spearman correlation coefficients, Student's t test or ANOVA. Result: Oxidized LDL and Malondialdehyde serum levels in patient groups were significantly higher than control groups (p<0.05). Furthermore, serum concentrations of OX-LDL in double-vessel disease were significantly higher as compare with control and no-vessel groups and triple vessel disease were significantly higher as compare with single vessel disease (p<0.05). Serum concentrations of MDA in double-vessel disease were significantly higher as compare with control and no-vessel groups and triple vessel disease were significantly higher as compare with single vessel disease (p<0.05). Conclusion: Elevated serum levels of OX-LDL and MDA indicate potential role in atherogenesis leading to CAD. There for our findings suggest that determination of serum OX-LDL and MDA levels can be useful as diagnostic and monitoring markers in patients with CAD and its extent.
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