Abstract
Introduction: Vitronectin (VN), malondialdehyde (MDA) and high-sensitivity C-reactive rotein (hs-CRP) are cooperative agents involved in the atherosclerosis process. The study was conducted to assess the correlation of VN, MDA and hs-CRP with the severity of coronary artery disease (CAD). Methods: Parameters such as serum VN, MDA and hs-CRP were measured in 250 subjects including 200 patients with angiographically diagnosed CAD (50 subjects with non-significant CAD, 50 with single vessel disease, 50 with double vessel disease, and 50 with triple vessel disease) and 50 CAD-free subjects as a control group. Serum VN was measured with ELISA; MDA was measured based on reaction with thiobarbituric acid (TBA); and hs-CRP level was measured by a Commercial Kit by Immunoturbidimetry. Results: Serum VN, MDA and hs-CRP were significantly higher in patient groups compared to control group (P < .05). The mean value of MDA between 1 vessel and 3 vessel groups had significant difference (P = .01), also mean value of MDA between 2 vessel and control group and normal group showed significant difference (P < .001). The difference of MDA between 3 vessel and normal and 1 vessel and control group was significant (P < .001). Conclusion: The association and correlation between VN, MDA and hs-CRP indicate their involvement in the atherosclerosis process that may lead to progression of CAD. Also, these findings suggested that serum levels of VN, MDA and hs-CRP can help as diagnostic and monitoring markers in CAD patients and as markers of disease severity.
Highlights
Vitronectin (VN), malondialdehyde (MDA) and high-sensitivity C-reactive rotein are cooperative agents involved in the atherosclerosis process
VN binds to the multiple ligands, such as integrins, plasminogen activator inhibitor (PAI-1), urokinase plasminogen activator receptor (UPAR), complement-7, collagen, and heparin
These relations indicate that VN is implicated as a regulator of various physiological processes including peri-cellular proteolysis, coagulation, fibrinolysis, complement mediated immune responses, cell migration and attachment.[4,5]
Summary
Coronary artery diseases (CAD) account for one of the major worldwide causes of morbidity and mortality. High levels of VN mRNA were detected in many other organs, including brain, heart, testes, thymus, skeletal muscles, lungs and uterus.[3,4] VN is a major plasma protein which have found in the granules-α of blood platelets and in extracellular matrix of many tissues.[1,4] VN binds to the multiple ligands, such as integrins, plasminogen activator inhibitor (PAI-1), urokinase plasminogen activator receptor (UPAR), complement-7, collagen, and heparin These relations indicate that VN is implicated as a regulator of various physiological processes including peri-cellular proteolysis, coagulation, fibrinolysis, complement mediated immune responses, cell migration and attachment.[4,5] VN serves a exceptional regulatory linkage between cell adhesion and physiological proteolysis.[5,6] Numerous studies have mentioned that accumulation of free radicals has vital and causative role in the pathogenesis of atherosclerosis.[7,8] Lipids especially low density lipoprotein (LDL) are many susceptible to be attacked by free radicals. We prospectively tested whether parameters including VN, MDA and hs-CRP correlates together in these patients
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