Association of neuregulin 1 gene SNPrs2954041 polymorphisms with schizophrenia and cognitive function

Abstract

Objective To study the association of neuregulin 1(NRG1) gene SNPrs2954041 polymorphisms with schizophrenia and cognitive function. Methods 70 psychiatric patients were selected as observation group, 70 healthy persons were selected as control group.NRG1 gene SNPrs2954041 polymorphism was detected, and the patients' cognitive function and neurological NSS score were evaluated. Results The differences of SNPrs2954041 polymorphism genotype and allele frequencies between the two groups were statistically significant(χ2=35.412, 29.341, all P=0.000). The differences in genotype and allele frequencies between the male observation patients and male control group were statistically significant(χ2=24.571, 18.391, all P=0.000). The differences in genotype and allele frequencies between female the observation patients and female control group were statistically significant(χ2=14.145, 13.024, all P=0.000). The difference of memory understanding among the three groups was statistically significant(F=3.781, P=0.031). The difference of digit span, correct number, errors number, errors continued number, non-sustained errors number in three groups showed no significant differences(F=0.702, 0.125, 0.089, 0.692, 0.113, P=0.498, 0.882, 0.927, 0.512, 0.748), the difference of neurological soft signs score of T/T genotype[(6.79±0.55)points], T/G genotype[(6.88±0.51)points]and G/G genotype[(6.53±0.39)points]in schizophrenia group was not statistically significant(F=0.142, P=0.843). Conclusion NRG1 gene SNPrs2954041 polymorphism was related to schizophrenia and cognitive function in patients with schizophrenia. Key words: Schizophrenia; Neuregulin 1 gene; Cognitive