Abstract
BackgroundLectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays an important role in the pathophysiology of atherosclerosis and thrombosis. This study is aimed at evaluating the potential association of 3’-UTR-C188T and G501C in LOX-1 gene with cerebral infarction.MethodsA total of 386 patients with cerebral infarction and 386 healthy controls were included in the study, which were unrelated Chinese Han population in the Liaoning Province of northern China. The single nucleotide polymorphisms, 3’-UTR-C188T and G501C, were analyzed by polymerase chain reaction–ligation detection reaction method.ResultsThe frequencies of CC + GC genotype, GC genotype and C allele of G501C in the patients with cerebral infarction were significantly higher than those in the controls (P < 0.01, P < 0.01, P = 0.04, respectively). The correlation still remained after adjusting for confounding risk factors of cerebral infarction. In addition, no significant association was observed between 3’-UTR-C188T and cerebral infarction.ConclusionsThe study indicated that the G501C variant in LOX-1 gene may be associated with susceptibility to cerebral infarction, independent of other common risk factors, in northern Chinese Han population.
Highlights
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays an important role in the pathophysiology of atherosclerosis and thrombosis
The genotype and allele frequencies of two LOX-1 gene polymorphisms in patients and control subjects were shown in Tables 2 and 3
The GC genotype (35.0%) of G501C was represented at an increased frequency in the group of patients (OR = 1.596, 95% confidence intervals (CI) = 1.166-2.183, P < 0.01)
Summary
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays an important role in the pathophysiology of atherosclerosis and thrombosis. Stroke is the second most common cause of death and the leading cause of long-term disability worldwide [1]. In China, with 1.4 billion populations, the annual stroke mortality rate has exceeded heart disease to become the leading cause of death [2]. As the most common type of stroke, accounts for about 43.7% to 78.9% of all strokes in China [4]. Many studies have demonstrated that cerebral infarction is a heterogeneous disease with a complex etiology involving both genetic and environmental contributions [5,6]. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a trans-membrane glycoprotein which belongs
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