Abstract
To determine whether mitochondrial DNA (mtDNA) variations are associated with schizophrenia, 313 patients with schizophrenia and 326 unaffected participants of the northern Chinese Han population were included in a prospective study. Single-nucleotide polymorphisms (SNPs) including C5178A, A10398G, G13708A, and C13928G were analyzed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). Hypervariable regions I and II (HVSI and HVSII) were analyzed by sequencing. The results showed that the 4 SNPs and 11 haplotypes, composed of the 4 SNPs, did not differ significantly between patient and control groups. No significant association between haplogroups and the risk of schizophrenia was ascertained after Bonferroni correction. Drawing a conclusion, there was no evidence of an association between mtDNA (the 4 SNPs and the control region) and schizophrenia in the northern Chinese Han population.
Highlights
Schizophrenia is a chronic, severe metal dysfunction
Based on sequences of the hypervariable regions and polymerase chain reaction (PCR)-RFLP fragments in the coding region, the 326 samples in the control group were divided into haplotypes; the samples in the patient group were divided into 301 haplotypes (S1 and S2 Tables)
No associations were detected between 4 Single-nucleotide polymorphisms (SNPs) and schizophrenia in the northern Chinese Han population
Summary
Schizophrenia is a chronic, severe metal dysfunction. Clinical manifestations of schizophrenia vary tremendously, and the pathogenesis of this disease is unclear. Results of studies in which twins or adopted children were associated with occurrence of schizophrenia indicated that genetics and environmental factors together can produce this disease [1]. It was reported that the rate of mental illness among offspring was higher for those with a maternal history of mental illness than for those with a paternal history [2]. Patients with mitochondrial disease were more likely to exhibit symptoms of mental illness [3]. The risk of schizophrenia might be related to mitochondrial dysfunction
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