Abstract
Background: The existing literature reports results on the association of lipid parameters with the level of insulin secretion and the risk of arterial hypertension. Objective: This study evaluated the role of the insulin dosage and lipid fractions in the risk of arterial hypertension in type 2 diabetic patients in Western Algeria. Methods: This was a cross-sectional observational study involving 101 subjects with type 2 diabetes mellitus. The data collected was about the biodemographic profile of the participants. We performed multiple regressions to test the effect of insulin concentration on the parameters studied. Results: The multiple regression analytical study showed that HOMA-IR, BMI and waist circumference were predictors for the insulinemia response variable (P<0.05). It should be noted that in insulinopenia, insulin secretion is positively and significantly correlated with non-HDL-C (P=0.037), and it is also significantly and positively correlated with LDL-C (P=0.042). Multiple regression also shows that SBP and DBP are significantly and positively related to insulin resistance. Our data suggest a possible direct relationship between fasting insulin and blood pressure. Conclusion: Monitoring of circulating insulin concentrations is critically important in a population of type 2 diabetics.
Highlights
The question is whether the association of lipid fractions with the level of insulin secretion and the risk of arterial hypertension, reported in the literature, prevails in our study population.With regard to the association of lipid parameters with insulin secretion level and risk of arterial hypertension, the existing literature reports controversial results, in a specific sex or ethnic subgroup [1].Some epidemiological studies, including cross-sectional and longitudinal studies have indicated that insulin levels secreted are associated with Blood Pressure (BP) as well as the incidence of arterial hypertension [2].It has been well established that high blood pressure tends to coexist with diabetes [3]
Monitoring of circulating insulin concentrations is critically important in a population of type 2 diabetics
Multiple regression shows that SBP and DBP are significantly related to insulin resistance
Summary
The question is whether the association of lipid fractions with the level of insulin secretion and the risk of arterial hypertension, reported in the literature, prevails in our study population.With regard to the association of lipid parameters with insulin secretion level and risk of arterial hypertension, the existing literature reports controversial results, in a specific sex or ethnic subgroup [1].Some epidemiological studies, including cross-sectional and longitudinal studies have indicated that insulin levels secreted are associated with Blood Pressure (BP) as well as the incidence of arterial hypertension [2].It has been well established that high blood pressure (arterial hypertension) tends to coexist with diabetes [3]. The question is whether the association of lipid fractions with the level of insulin secretion and the risk of arterial hypertension, reported in the literature, prevails in our study population. With regard to the association of lipid parameters with insulin secretion level and risk of arterial hypertension, the existing literature reports controversial results, in a specific sex or ethnic subgroup [1]. Some epidemiological studies, including cross-sectional and longitudinal studies have indicated that insulin levels secreted are associated with Blood Pressure (BP) as well as the incidence of arterial hypertension [2]. Among the limited prospective studies on the association of insulin levels with the incidence of arterial. The existing literature reports results on the association of lipid parameters with the level of insulin secretion and the risk of arterial hypertension
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