Abstract
MACROPHAGES are involved in the induction of the immune response to various antigens1,2 and ultrastructural observations suggest a close relationship between macrophages, lymphocytes and a variety of immunocompetent cells3,4, although the antibody specificities of the latter have not been demonstrated. But by using enzymes first as antigens and subsequently as markers it is possible to observe the cells producing anti-enzyme antibody (AEA) by light5,6 and electron microscopy7,8. Straus9, using the former technique, suggested that there was a relationship between antigen-containing macrophages and antibody-producing cells. We are now studying the response in mouse popliteal lymph node to two different enzymes, horse radish peroxidase and E. coli alkaline phosphatase and our findings also suggest a close relationship between macrophages and cells synthesizing AEA. Furthermore, we have found that a high proportion of the macrophages phagocytose other cells, including many specific antibody-producing cells.
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