Abstract
Methods A cross-sectional analysis was performed among 1633 asymptomatic adults who underwent colonoscopy examinations during routine health check-ups at the First Affiliated Hospital, College of Medicine, Zhejiang University, between 2015 and 2018. Results A total of 449 (27.50%) participants were diagnosed with colorectal polyps, and those with colorectal polyps had significantly higher hemoglobin levels than did those without colorectal polyps. Hemoglobin levels were positively associated with the prevalence of colorectal polyps, with rates of 16.43%, 26.20%, 32.17%, and 35.87% among participants with hemoglobin levels in the first, second, third, and fourth quartiles, respectively (P for trend < 0.001). Stepwise multiple regression analysis showed that elevated hemoglobin levels independently increased the risk of colorectal polyps (odd ratio = 1.017; 95% confidence interval: 1.008–1.026). Conclusion Elevated hemoglobin levels were significantly and independently associated with the prevalence and risk of colorectal polyps in asymptomatic adults.
Highlights
Colorectal cancer (CRC) is ranked as the second most common cancer diagnosed in women and the third most common cancer in men worldwide [1]
Hemoglobin levels were positively associated with the prevalence of colorectal polyps, and this association was independent of obesity
Our results showed that elevated hemoglobin independently increased the risk of colorectal polyps
Summary
Colorectal cancer (CRC) is ranked as the second most common cancer diagnosed in women and the third most common cancer in men worldwide [1]. The incidence and mortality of CRC have shown an increasing trend in China over the past decade [2] This trend can be attributed to many factors, including rapid urbanization, an aging population, and a shift toward a more sedentary lifestyle and unhealthy dietary habits [2]. CRCs that arise sporadically result from the stepwise accumulation of multiple somatic mutations [4]. This hypothesis is supported by pathological, epidemiological, and observational clinical data, and it is widely accepted that early detection and resection of these polyps may prevent CRC-related death [5]. Identifying risk factors and associations of certain inexpensive laboratory parameters can be useful in targeting groups of people for colonoscopy who are generally regarded as average-risk individuals
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