Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans.

Hassan Brim,Guillermo I Pérez-Pérez,Mehdi Nouraie,Edward Lee,Hassan Ashktorab,Marwah Zahaf,Duane T Smoot,Adeyinka O Laiyemo,Hadie Razjouyan

doi:10.1186/1471-2407-14-296

Hassan Brim, Guillermo I Pérez-Pérez + Show 7 more

Open Access

https://doi.org/10.1186/1471-2407-14-296

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Abstract

BackgroundGastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population. We aimed to investigate whether gastric H. pylori infection is associated with colorectal polyps in African Americans.MethodsMedical records of African Americans, 40 years and older (n = 1256) who underwent bidirectional gastrointestinal endoscopy on the same day were reviewed. H. pylori status was assessed by immunohistochemistry on gastric specimens. Colorectal polyps were confirmed by histological examination of colorectal biopsies. A subset of serum samples from healthy and polyp-bearing patients (n = 163) were analyzed by ELISA for anti-H. pylori and anti-CagA antibodies. The crude and adjusted effect of H. pylori on the risk of colorectal adenoma and polyp were computed by logistic regression models.ResultsThe prevalence of colorectal polyps and adenomas were 456 (36%) and 300 (24%) respectively. Colorectal polyps were more prevalent in gastric H. pylori infected than non-infected subjects [43% vs. 34%; Odds Ratio (OR) (95% CI): 1.5 (1.2-1.9), P = 0.001]. Patients with H. pylori-associated chronic active gastritis were at high risk to have adenomas [Unadjusted OR (95% CI): 1.3 (1.0-1.8); P = 0.04]. There was no difference in histopathology, size, or location of polyps with respect to H. pylori status. Gastric H. pylori infection, age, male gender and high risk clinical presentations were independent risk factors for colorectal polyps. Serological testing also revealed a higher prevalence of H. pylori and its toxin Cag-A in polyp patients vs. non polyp patients’ sera, although in a non-statistically significant manner.ConclusionsThis study showed that current gastric H. pylori infection is associated with an increased risk of colorectal polyps in African Americans. Patients with H. pylori induced gastritis may benefit from early screening colonoscopy as a preventative measure for colorectal cancer.

Highlights

Gastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population
We sought to determine whether current gastric H. pylori infection was associated with the presence of colorectal polyps in a population at high risk for colorectal lesions
Size and location were not correlated to H. pylori status (Table 1)

Summary

Introduction

Gastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population. We aimed to investigate whether gastric H. pylori infection is associated with colorectal polyps in African Americans. A recent meta-analysis of the correlation between H. pylori and extra-gastric malignancies revealed a modest statistically significant relationship of H. pylori infection with both colon cancer and polyps [32]. H. pylori’s infection and colorectal lesions appear to be more common in African Americans compared to the Caucasian population in the US [1,33]. We sought to determine whether current gastric H. pylori infection was associated with the presence of colorectal polyps in a population at high risk for colorectal lesions

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