Abstract
BackgroundCognitive deficits are common in patients with bipolar disorder (BD). Abnormal high density lipoprotein (HDL) levels have been implicated in cognitive deficits associated with ageing and neurodegenerative disorders. The present study aimed to investigate serum HDL levels, cognitive deficits and their association in patients with BD.MethodsThirty-seven patients with BD and 37 gender- and age-matched healthy controls (HCs) were recruited in a case–control study. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and serum HDL levels were measured using enzymatic colourimetry.ResultsThere was no difference in serum HDL levels between patients with BD and HCs after adjusting for gender, age, education and body mass index (BMI). Cognitive test scores in patients with BD were significantly lower than those in HCs except for the visuospatial/constructional index after adjusting for confounding variables. Serum HDL levels were positively correlated with RBANS total score and language score in patients with BD. Stepwise multiple regression analysis showed that serum HDL levels were significantly correlated with RBANS total score and subscale scores on immediate memory and language in patients with BD after adjusting for confounding factors.ConclusionsOur findings suggest that patients with BD had poorer cognitive performance than HCs except for the visuospatial/constructional domain, and decreased serum HDL levels were correlated with cognitive deficits, especially in immediate memory and language domains in patients with BD.
Highlights
Cognitive deficits are common in patients with bipolar disorder (BD)
There was no difference in gender, age, education and body mass index (BMI) between patients with BD and healthy controls (HCs)
There was no difference in serum high density lipoprotein (HDL) levels between patients with BD and HCs (F = 0.04, df = 73, P = 0.85)
Summary
Cognitive deficits are common in patients with bipolar disorder (BD). Abnormal high density lipoprotein (HDL) levels have been implicated in cognitive deficits associated with ageing and neurodegenerative disorders. The present study aimed to investigate serum HDL levels, cognitive deficits and their association in patients with BD. Bipolar disorder (BD) is a severe and heritable psychiatric illness with a prevalence of approximately 1–2%. It is characterized by recurrent episodes of depression and mood elevation (Merikangas et al 2011; Waraich et al.2004). Previous studies have reported that BD patients have deficits in executive function, memory and attention (Palazzo et al 2017; Robinson et al 2006). Cognitive deficits may be a potential endophenotype for BD, but the underlying pathophysiology of cognitive deficits in patients with BD is unclear
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