Abstract

Background; Stroke is a global health problem. Stroke is responsible for major disabilities in adult population, and is 2 nd leading cause of deaths all over the world. Different studies have reported dyslipidemia as major cause of stroke in different populations. Objective; To determine the association of non – modifiable risk factors such as diabetes, hypertension and obesity with dyslipidemias in patients with ischemic stroke at Nishtar Hospital Multan. Material and methods; All the cases of stroke (n=240) Patients having finding on CT scan brain (plain) consistent with ischemic stroke of either sex aged less than 80 years were enrolled in this cross-sectional study from department of Medicine, Nishtar Hospital, Multan. Complete history about onset of illness, diabetes, hypertension and cardiac illness of the patients was taken. Baseline laboratory investigations including lipid profile and Hb A 1 c were done. Results; Of these 240 study cases, 155 (64.6 %) were male patients and 85 (35.4%) were female patients. Mean age of our study cases was 68.37 ± 14.55 years (with minimum age was 34 years while maximum age was 79 years). Out of these 240 study cases, 138 (57.5 %) were from poor families, 53(22.1 %) were diabetic and only 11 out of 53 (20.75%) had controlled glycemic levels. Hypertension was present in 182 (75.8%) of our study cases and 39 (16.3 %) were obese. Smoking was present in 101 (42.1%), previous history of stroke was present in 35 (14.6%) and 83 (34.6%) were Saraikis. Mean duration of illness was 2.24 ± 0.53 months and 135 (56.3%) had disease duration more than 1 month. Mean serum cholesterol level was 202.06 ± 45.36 mg/dl, mean serum LDL level was 91.13 ± 10.24 mg/dl, mean serum triglyceride level was 147.51 ± 20.21 mg/dl and mean serum HDL level was 42.92 ± 3.85 mg/dl and dyslipidemia was present in 85 (35.4 %). Conclusion; Frequency of dyslipidemia was high among patients having ischemic stroke in our study. Dyslipidemia was significantly associated with diabetes, hypertension, obesity, smoking, previous history of stroke and ethnicity. Early diagnosis followed by timely management can help reduce disease morbidity and improve clinical outcomes in these patients. Keywords; ischemic stroke, dyslipidemia, frequency. DOI : 10.7176/JMPB/58-03 Publication date : August 31 st 2019

Highlights

  • MBBS, Abstract; Background; Stroke is a global health problem

  • Stroke patients in low income countries are younger than their western counterparts and the burden of sustained disability in survivors is greater as well as total deaths from stroke in developing countries account for 85.5% of stroke deaths worldwide[4]

  • The purpose of this study is to determine the frequency of dyslipidemias in the patients of ischemic stroke in the targeted population

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Summary

Introduction

MBBS, Abstract; Background; Stroke is a global health problem. Stroke is responsible for major disabilities in adult population, and is 2nd leading cause of deaths all over the world. Objective; To determine the association of non – modifiable risk factors such as diabetes, hypertension and obesity with dyslipidemias in patients with ischemic stroke at Nishtar Hospital Multan. Dyslipidemia was significantly associated with diabetes, hypertension, obesity, smoking, previous history of stroke and ethnicity. According to World Health Organization (WHO) estimates for the year 2020, stroke will remain the 2nd leading cause of death along with ischemic heart disease both in developing and developed countries[3, 6,7,8]. Ischemic Stroke occurs as a result of an obstruction within a blood vessel supplying blood to the brain It accounts for 60-90% percent of all stroke cases in Pakistan. The purpose of this study is to determine the frequency of dyslipidemias in the patients of ischemic stroke in the targeted population

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