Abstract
Background: Evidences prove that endothelial cell and altered endothelial cell function play an important role in the pathogenesis of preeclampsia. Therefore serum lactate dehydrogenase (LDH) is useful biochemical markers reflecting the severity of the occurrence of preeclampsia. Objective: Determination of serum lactate dehydrogenase (LDH) in severe preeclamptic pregnant women. Methods: This is the case-control hospital based study carried in the Al Azhar Medical College and Super speciality Hospital, Thodupuzha. Normal pregnant women (n=55) and women with severe preeclampsia (n=63) were included in the study. Both the groups were in their third trimester and of same age and same gestational age. Serum LDH levels were measured by continuous spectrophotometric pyruvate method for both groups. Results: Higher values of serum lactate dehydrogenase (LDH) were found in severe preeclamptic women compared with normal pregnant women in third trimester. Conclusion: Elevated levels of serum LDH indicates the tissue damage and might be the cause of the occurrence of preeclampsia.
Highlights
Preeclampsia is a clinical manifestation characterized by hypertension, proteinuria and edema that occurs after 20th week of pregnancy
Serum lactate dehydrogenase (LDH) is most often measured to evaluate the Manuscript received: 5th September 2016 Reviewed: 15th September 2016 Author Corrected: 23rd September 2016 Accepted for Publication: 30th September 2016 presence of tissue damage associated with endothelial damage
Study population: Study was divided into two groups. 63 pregnant women clinically diagnosed as preeclampsia during third trimester (28-40 weeks) with the age 18-36 years admitted in obstetrics
Summary
Preeclampsia is a clinical manifestation characterized by hypertension, proteinuria and edema that occurs after 20th week of pregnancy It is a multisystem disorder of pregnancy with potentially severe consequences for both mother and child [1]. Dysfunction of endothelial cells can contribute to inappropriate vasoconstriction and platelet aggregation which are early signs of hypertension [7] These are multisystem disorders and lead to a lot of cellular death. LDH is an intracellular enzyme and its level is increased in these women due to cellular death This can be further used as help in making decision, regarding the management strategies to improve the maternal and fetal outcome. Results: Higher values of serum lactate dehydrogenase (LDH) were found in severe preeclamptic women compared with normal pregnant women in third trimester. Conclusion: Elevated levels of serum LDH indicates the tissue damage and might be the cause of the occurrence of preeclampsia
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