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Abstract
Introduction: Pre-eclampsia is a multi-system disorder of unknown etiology and a major cause of maternaland perinatal complications. LDH is an intracellular enzyme and is increased when there isincreased cell death. As pre-eclampsia leads to cellular death, so LDH levels can beusedtoassesstheseverityofdisease. Aim: To study the correlation of levels of serum LDH in women with preeclampsia on maternal and perinatal outcome. Objectives: To correlate the maternal and perinatal outcomes with serum LDH levels. To assess serum LDH as a marker for severity of preeclampsia. Materials and Methods: A prospective comparative studywas conducted over a period of 18 months from November 2016 to April 2018 in the department of Obstetrics and Gynecology, Sri Siddhartha Medical Hospital, Tumakuru. Out of 180 women studied, 100 were normal pregnant women, 40 patients were having mild preeclampsia and 40 patients were having severe preeclampsia. The two groups and subgroups were studied based on age, gravidity, trimester, investigations, maternal and perinatal outcome, complications and follow up. Results: Higher values of LDH were found in mild and severe preeclamptic women than those of normal pregnant women in third trimester and was statistically significant. Severe lypreec lamptic patients had increased LDH levels which in association with investigations, outcome, complications and follow up was significant. Conclusion: LDH is a useful biochemical marker and can be considered as a supportive prognostic tool thatreflects the severity and complications of preeclampsia. Identification of high-risk patients, theirclose monitoring, and correct management may prevent these complications.
Highlights
Pre-eclampsia is a multi-system disorder of unknown etiology and a major cause of maternal and perinatal complications
Estimation of serum Lactate Dehydrogenase: Plain blood sample was collectedfor analysis of Lactate dehydrogenase (LDH) which was done in fully automated biochemistry analyzer
Raised LDH is associated with preeclampsia and higher the LDH levels more are the chances of complications
Summary
Pre-eclampsia is a multi-system disorder of unknown etiology and a major cause of maternal and perinatal complications. As pre-eclampsia leads to cellular death, so LDH levels can beused to assess the severity of disease. Aim: To study the correlation of levels of serum LDH in women with preeclampsia on maternal and perinatal outcome. Objectives: To correlate the maternal and perinatal outcomes with serum LDH levels. Severe lypreec lamptic patients had increased LDH levels which in association with investigations, outcome, complications and follow up was significant. Hypertensive disorders complicate 5 to 10 percent of all pregnancies, incidence varies among different hospitals, regions, and countries [1]. These disorders are a major cause of maternal and perinatal mortality and morbidity worldwide [2]. Manuscript received: 18th January 2019 Reviewed: 28th January 2019 Author Corrected: 2nd February 2019 Accepted for Publication: 6th February 2019
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