Assessment of serum and salivary lactate dehydrogenase and uric acid levels in oral squamous cell carcinoma patients

Abstract

Background: The present study was conducted to assess serum and salivary lactate dehydrogenase and uric acid levels in oral squamous cell carcinoma patients. Materials & Methods: 62 patients of oral squamous cell carcinoma patients of both genders were enrolled. Patients were divided into two groups. Group I had SCC patients and group II had normal subjects. In all, serum and unstimulated saliva samples obtained and subjected to assessment of lactate dehydrogenase and uric acid levels. Results: The mean serum LDH level (U/L) in group I was 342.8 and in group II was 246.0. The mean salivary LDH level (U/L) in group I was 652.8 and in group II was 248.4. The difference was significant (P< 0.05). The mean serum uric acid (mg/dl) in group I was 6.98 and in group II was 5.12. The mean salivary uric acid in group I was 5.92 and in group II was 5.26. The difference was significant (P< 0.05). Conclusion: OSCC patients had elevated level of serum and salivary LDH and uric acid.