Abstract
Background: The quality of single donor platelets (SDP) in terms of yield influences the platelet recovery in the recipient. Various donor factors such as predonation platelet count and hemoglobin concentration may affect platelet yield. The aim of present study was to assess the effect of various donor factors on platelet yield and effect of plateletpheresis on hematological values of donors. Materials and methods : A total of 171 plateletpheresis procedures were performed using continuous flow cell separator (Amicus Automated Blood Collection System version 2.52/3.1) were evaluated for platelet yield. The pre and post donation hematological values such as platelet count, hemoglobin (Hb) concentration, mean platelet volume (MPV) and platelet distribution width (PDW) were measured in all blood donors. Results : The mean platelet yield was 3.8 + 1.65 X 10 11 /unit. The platelet yield correlated positively (r = 0.446, p < 0.001) with donor pre platelet count and negatively (r =- 0.004, p = 0.954) with donor pre-Hb. There was significant increase (p < 0.001) in Hb concentration and platelet count decreased significantly (p<0.001) after each procedure. While, there was no significant decease in MPV and PDW after each procedure. Conclusion: All transfusion centers should have their own plateletpheresis donor data based on demographic and hematological characteristics of the donor population. This will ensure donor safety, product quality and an effective donor registry.
Highlights
Single donor platelet (SDP) products are preferred over random donor platelet (RDP) products due to several advantages, such as support for patients with special needs, supplementation of platelet inventory, limited donor exposure and reduced transmission of infections[1,2,3]
The study included 171 (169 males and 2 females; aged from 20 to 52 years) plateletpheresis procedures performed on continuous flow cell separator (Amicus Automated Blood Collection System version 2.52/3.1) using closed system apheresis kits over a period from January 2009 to July 2010 at our department
The present study addressed the changes in hematological parameters after plateletpheresis and influence of donor hematological parameters on the platelet yield
Summary
Single donor platelet (SDP) products are preferred over random donor platelet (RDP) products due to several advantages, such as support for patients with special needs, supplementation of platelet inventory, limited donor exposure and reduced transmission of infections[1,2,3]. The aim of present study was to analyze various donor factors such as predonation platelet count, hemoglobin (Hb) concentration, mean platelet volume (MPV) and platelet distribution width (PDW) on the yield of platelets and to determine the effect of plateletpheresis procedures on donor hematological parameters. The quality of single donor platelets (SDP) in terms of yield influences the platelet recovery in the recipient. Various donor factors such as predonation platelet count and hemoglobin concentration may affect platelet yield. The pre and post donation hematological values such as platelet count, hemoglobin (Hb) concentration, mean platelet volume (MPV) and platelet distribution width (PDW) were measured in all blood donors.
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