Effect of donor variables on yield in single donor plateletpheresis by continuous flow cell separator

Abstract

The quality of single donor platelets (SDPs) in terms of yield influences platelet recovery in the recipient. Various donor factors such as pre-donation platelet count and hemoglobin (Hb) concentration affect the platelet yield. We studied the influence of pre-donation donor clinical and laboratory factors such as gender, age, weight of the donor, platelet count and Hb on the platelet yield. A total of 94 plateletpheresis procedures performed on continuous flow cell separator (CS3000, Baxter Healthcare, Round Lake, IL, USA) were evaluated for platelet yield. A relationship between pre-donation donor variables and yield of platelets was studied using the Pearson correlation. The mean platelet yield was 2.8 ± 0.73 × 10 11. While a direct relationship was observed between pre-donation platelet count and yield ( r = 0.50, p < 0.001), no such correlation was noticed with donor Hb concentration ( r = −0.10, p > 0.005). Similarly, no correlation was observed between gender ( r = 0.05), age ( r = 0.11) and weight ( r = 0.18) of the donor with yield. Optimization of platelet yield, which is influenced by pre-donation platelet count, is an emerging issue in blood transfusion services. Identification of such factors may help in selecting donors to obtain higher platelet yields and consequently better clinical outcome.