Abstract
Background: Faecal calprotectin (FC) is an easily applicable faecal surrogate marker of intestinal inflammation; it has provided a new means for objectively assessing disease activity in patients with various bowel diseases. In this study, the authors assessed levels of FC before colonoscopy preparation, during bowel cleansing and 1 week after colonoscopy. Methods: This cross-sectional study was conducted on 58 individuals referred to Razi Hospital, Rasht, Iran, for colonoscopy between 2021 and 2022. For all individuals, stool sampling was repeated three times before colonoscopy, during bowel preparation and 1 week after colonoscopy. All demographical and clinical data were collected through a questionnaire. FC results, colonoscopy and pathology findings were also recorded. Results: The mean age of the participants was 48.22±11.69 years and approximately 62.1% were female. There was no statistically significant difference between the average levels of FC before colonoscopy preparation, during bowel cleansing and 1 week after colonoscopy (P>0.05). The average amount of FC at different time points was not significantly different in patients with abnormal histopathological results compared to individuals with normal findings (P>0.05). Conclusions: The study findings suggest that bowel cleansing and colonoscopy do not significantly alter FC levels.
Published Version
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