Arrhythmias in patients with cardiac amyloidosis

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Cardiac amyloidosis is characterized by the extracellular deposition of fibrillar proteins in various heart parts, which can lead to restrictive heart failure and cardiac arrhythmias. In many cases, the incidence of both atrial and ventricular arrhythmias and conduction disorders is high and underestimated. The clinical picture often manifests itself only at the time of extensive involvement of the muscular and conduction system of the heart. Secondary to amyloid infiltration, bradyarrhythmias, and conduction disorders can occur, however, the timing of pacemaker implantation remains unclear. Many commonly used drugs may be poorly tolerated by patients with cardiac amyloidosis.