Abstract
As described in the inaugural chapter, the Infinite Horizon (IH) impactor was developed and first characterized (Scheff et al., Journal of Neurotrauma 20:179–193, 2003) to produce graded behavioral and correlative morphological changes in adult female Sprague-Dawley rats and their spinal cords following varying severities of contusion spinal cord injuries (SCI) at thoracic spinal level 10 (T10) in adult rats. Since that time, the IH device has become a widely used contusion SCI model, and more importantly, its tractability has allowed its adaptation to elicit different injury severities (impact forces) at different spinal levels, in both rats and mice; and the accompanying distinct behavioral recovery outcome measures.
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