Applications of intelligent biomaterials in cancer immunotherapy: A review

Abstract

Intelligent biomaterials can adapt to the changingphysiological parameters and external stressors, and they tend to provide an influence on many facets of medical technology. They have the ability to accelerate promising medicines and enhance the management of chronic ailments. They find utilization in the domains of regenerative medicine, drug delivery systems, medical gadgets, and immunotherapy. Cancer Immunotherapies, which uses a recipient’s immune-system to combat malignancy, is currently reinventing the domain of cancer treatment. Even though aiming T-cells has demonstrated to be a technologically effective restorative strategic approach for the majority of cancer immunotherapies, just a small number of people benefit from such initiatives. Recently, there has been a growing interest in studying the largely untapped innate immunity as a potential treatmentintervention tool. Via gene editing, metabolic labelling, synthetic complexation, lipophilic incorporation, and some other methods, sensibly proposed practical biomaterials have been employed to fabricateartificial functionalities on the cellular surface to provide an increased immunity against cancer and reduced toxicological effects. The biomaterials can be utilized in providing cell and/or tissue explicit better-refined modulation in immunity of a cancer patient. Thus, in the current review are discussing the advances in immunoengineering employing bio-materials and their implications in supporting specific procedures of cancer immune cell therapy, paying special emphasis on antibody-, cell-, immunomodulator-, and gene-based immunity concerned treatment strategies and their conjunction with pharmacological treatments. The limitations and prospects of using biomaterials design technologies in the creation of potential cancer immunotherapies are highlighted.