Abstract
Deep eutectic solvents are liquid mixtures of solid components at room temperature, which present exceptional properties: high solvent capacity, high biodegradation, low volatile organic compound character, and relatively low toxicity. Furthermore, there are an important number of DES described, formed by different components and ratios, and thus, the studied applications are also numerous. In this review, we focused on the applications related to health. One of the most promising applications of DES is the development of oral liquid formulations of poorly soluble active pharmaceutical ingredients, although it currently remains at an early stage. We have analyzed the potential and limitations of DES with this regard. Furthermore, DES have been used as synthesis media. In this work, we revised the use of DES to obtain bioactive natural products via synthesis or extraction process. Finally, the usefulness of DES in other interesting applications for promoting health has been also examined: this is the case of genomics studies, nano-carriers for the encapsulation of anticancer drugs or stabilization of samples for medical purposes.
Highlights
The scientific and technological progress carried out over time has resulted in many improvements in the quality of life, and in visible damage and overexploitation of natural sources
We focused on the applications related to health
One of the most promising applications of deep eutectic solvents (DESs) is the development of oral liquid formulations of poorly soluble active pharmaceutical ingredients, it currently remains at an early stage
Summary
The scientific and technological progress carried out over time has resulted in many improvements in the quality of life, and in visible damage and overexploitation of natural sources. In the last few years, a new class of substances have emerged as promising green solvents, the so-called deep eutectic solvents (DESs) These new DESs have emerged as a realistic and tighter alternative than previous attempts [5,6], providing a new type of substance with better environmental and health properties, low production costs [7], and better biodegradability profiles [8]. DESs show eral properties such as low preparation costs, environmentally-friendly2,owf 18ide pola range, low vapor pressure and volatility, non-inflammability, thermal and chemical bility, biodegradability, low toxicity, etc. They present many possible c binacthiloonrisdetoorobbettaainine, dbuiftfoetrheenrstskuicnhdass tohfymsooll,vmenentsthodle, dpeecnadnoinicg, oor nlautrhiceaircidusheasve[1be4e,1n5].
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