Application of whole-body magnetic resonance diffusion weighted imaging in evaluating the chemotherapy response for lung cancer

Abstract

Objective To study the clinical value of whole-body magnetic resonance diffusion weighted imaging(WB-DWI) in evaluating the chemotherapy response for lung cancer, thus to provide evidence for optimizing clinical imaging examination. Methods From October 2017 to May 2018, 60 patients with lung cancer confirmed by histopathology in Linfen Central Hospital were selected.The patients underwent DWI examinations before chemotherapy and after two cycles of chemotherapy.The change of tumor size, distant metastasis and apparent diffusion coefficient(ADC) value were compared before and after chemotherapy.The correlation between the change rate of ADC value and the shrinkage rate of tumor size in the effective group was analyzed. Results Of 60 cases, 1 case had new cerebral metastases after chemotherapy.There were statistically significant differences in ADC value[(1.12±0.33)×10-3mm2/s vs.(1.56±0.40)×10-3mm2/s]and tumor size[(4.63±2.75)cm vs.(2.28±1.45)cm]between before and after chemotherapy in the effective group(t=-3.954, 4.711, all P<0.01). There was correlation between the change of ADC value and tumor size(r=0.34, P<0.05). Conclusion WB-DWI can not only detect the change of tumor size and distant metastasis quickly and effectively, but also can observe the microscopic changes of tumor cells by measuring ADC value.So it can predict the early therapeutic response of the tumor and make effective evaluation for the staging and chemotherapy response of lung cancer. Key words: Magnetic resonance imaging; Diffusion magnetic resonance imaging; Lung neoplasms; Drug therapy, Combination; Neoplasm metastasis; Neoplasm staging; Technology assessment, Biomedical; Forecasting