Abstract
The unrelated umbilical cord blood transplantation (UCBT) has been accepted by the public for the purity of umbilical cord blood, easy to obtain and so on, which provides a wider range of choice for hematopoietic stem cell transplantation (HSCT). Most of UCBT choose myeloablative conditioning (MAC) to reduce the relapse rate. MAC can increase the transplantation-related mortality (TRM), and it requires patients with good health status. But reduced-intensity conditioning (RIC) not only could be used to elderly or poor-body-condition patients, but also have lower TRM and enhance the quality of post-transplantation patients′ lives. In this paper, progress and problems of RIC-UCBT in treating malignant hematological diseases are reviewed. Key words: Cord blood stem cell transplantation; Transplantation conditioning; Hematologic neoplasms
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