Abstract

Unrelated umbilical cord blood (UCB) is one of ideal hematopoietic stem cell (HSC) source for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in treatment of hematologic malignancies. Because of lack of donor and cannot use the traditional donor lymphocyte infusion (DLI) treatment, once the patients occurred recurrence of primary disease after unrelated umbilical cord blood transplantation (UCBT), their treatment for recurrence of primary disease is very limited. In this paper, authors will review the treatment strategies for recurrence of primary disease after UCBT in patients with hematologic malignancies. Key words: Unrelated donors; Cord blood stem cell transplantation; Hematologic neoplasms; Recurrence

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