Abstract
Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)3-3×(NH2trz)3×](BF4)2 (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280–330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.
Highlights
Recent studies have demonstrated that Spin crossover (SCO) materials can potentially be employed as Magnetic resonance imaging (MRI) contrast agents[7,8]
The synthesized NPs 1 were dispersed in water and measured by transmission electron microscopy (TEM) to confirm that nanoparticulation had occurred
We observed that the T1 relaxation time of water molecules with or without any contrast agent becomes longer with increasing temperature
Summary
Recent studies have demonstrated that SCO materials can potentially be employed as MRI contrast agents[7,8]. Spin crossover (SCO) materials undergo a change in their spin state between high-spin (HS) and low-spin (LS) on exposure to external stimuli, i.e., temperature, pressure, magnetic field, and light irradiation. Such materials have been intensively investigated for use in applications such as information storage, sensor development, and display technologies[9,10,11]. SCO materials can in principle be employed as MRI contrast agents by using the change of their magnetism with temperature when the temperature of tumor cells is higher than nomal cells. D0: Density of the solvent in g cm−3. ds: Density of the solution in g cm−3. χMdia: Diamagnetic correction for the magnetic susceptibility in cm[3] mol−1
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