Application of single-cell sequencing technology in the study of cardiovascular development and diseases

Abstract

Single-cell sequencing technology has developed rapidly in recent years and has demonstrated its power in many fields, especially in the field of tumor-, immunity-, and stem cell-related researches, where it explains many biological laws that remained uncovered. In terms of cardiovascular disease, in spite of application in studies of atherosclerotic plaque and explaining the cellular heterogeneity in plaque formation, single-cell sequencing technology is relatively limited and is in its infancy. This article reviews the application of single-cell sequencing technology in cardiovascular field in recent years and makes a brief comparison with its application in other fields, hoping to point out the way for future research.