Abstract

The orthogonal function method has been applied to the simultaneous determination of nifuroxime and furazolidone in admixture without the need of preliminary separation. Two procedures are proposed. The first one involves measurement of a suitable solution of the mixture in the range from 309 nm to 359 nm with 10 nm intervals to determine nifuroxime, and in the range from 345 nm to 395 nm with 10 nm intervals to determine furazolidone. The second procedure involves determination of either components through measurement at the previously mentioned wavelength range while the absorbance of the partner component is measured at its λmax; correction of interference is carried out using an calculated absorbance ratio. Both methods were successfully applied to the analysis of market preparations and further application for routine analysis is recommended. Recoveries were in general between 97% and 102%.

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