Abstract
The orthogonal function method is applied to the determination of dihydrocodeine bitartrate as a minor component (5 mg) in presence of noscapine hydrochloride (25 mg) without separation. Another method based upon precipitating noscapine by a saturated solution of sodium acetate is also presented. Dihydrocodeine is determined in the filtrate using the orthogonal function method to correct for the unprecipitated fraction of noscapine. Standard deviation is 1.56 and 0.66 for direct and precipitation methods, respectively.
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