Abstract
Introduction: Among medicines which exhibit antidepressant effect, Syndnocarb is widely used. It is used in psychiatry, in narcological practice it is prescribed to patients with chronic alcoholism, in pediatrics – children with diseases of the central nervous system. In case of overdose, it has a toxic effect and may be the cause of poisoning. Therefore, it is necessary to have the express methods of its analysis sensitive and reliable. Purpose: To develop a method of spectrophotometric analysis of a siderine in the UV region of a spectrum suitable for its rapid detection in solutions and tablets. Methods: UV spectrophotometry method. Results: The method of identification of a drug of antidepressant action of Sydnocarb is proposed by the method of molecular absorption spectroscopy in the UV region of the spectrum. Selected optimal conditions for the development of analysis techniques. The character of spectra in various solvents (inorganic and organic) in acid, alkaline and neutral media is studied. The maxima of light absorption are determined, molar and specific light absorption coefficients are calculated in all the solvents studied, by which it can be quantified. The developed method is used to identify the syndocard in tablets. Conclusion: The elaborated procedure enables to quickly and reliably identify the Syndnocarb in solutions and tablets by the method of UV spectrophotometry in the nearrange region of the spectrum. The maxima of light absorption, molar and specific coefficients in such solvents are determined: potassium hydroxide, nitric acid, water, dichloroethane, ethanol and phosphate buffer solution. It has been established that Sydnocarb has two stripes of dressing in acidic, alkaline and neutral media, as well as in organic solvents. In the longwave region of the spectrum, a hypochromic effect (decrease in absorption intensity) is observed in all of these solvents. The molar and specific coefficients of light absorption are determined, which make it possible to carry out the quantitative determination of the sidecar in various objects.
Published Version
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