Abstract
Objective To investigate the role of nucleic acid detection in screening hepatitis B virus (HBV) infection of blood donors. Methods 30 025 blood donors from February to October 2016 in Central Blood Station, Huizhou were enrolled in this study. The enzyme linked immunosorbent assay (ELISA) and nucleic acid detection were used to detect hepatitis B virus detection. Results HBsAg in 29 095 blood samples was negative in ELISA assay, and 15 cases were positive for single reagent.45 blood samples were HBV positive in nucleic acid screening. A total of 34 samples were further confirmed as HBV infection in nucleic acid detection, and 2 cases were confirmed as HBsAg positive by ELISA. The screening rate of HBV positive for blood donors in nucleic acid screeningwas 0.15%, the HBsAg positive rate of ELISA was 0.11%, and the detection of HBsAg by using ELISA was sometimes easy to escape diagnosis or be misdiagnosed. Conclusion Nucleic acid detection is more accurate than ELISA in the detection of HBV infection in blood donors, which is helpful to further determine the blood safety of blood donors. Key words: Nucleic acid detection; ELISA detection; Blood donors; Hepatitis B virus
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