Application of human papillomavirus combined with thinprep cytology test in screening of cervical diseases

Abstract

Objective To investigate the application value of human papillomavirus (HPV) combined with thinprep cytology test (TCT) detection in screening of cervical cancer. Methods 276 patients were enrolled to have HPV and TCT tests at Department of Gynecology, Shanxi Cancer Hospital from January to December in 2014. Pathological examine was applied to the patients with abnormal results of HPV and TCT. The diagnostic value of HPV, TCT and their combinations was evaluated by the diagnostic sensitivity and the rate of coincidence with the pathological examine results. Results The sensitivity of HPV and its coincidence with the pathological examine results were 81.52 % (225/276) and 79.56 % (179/225), respectively, while those of TCT were 87.68 % (242/276) and 76.86 % (186/242), respectively. The coincidence rate between the combination method and the pathological examination was higher (94.71 % , 197/208) than the individual test. Conclusion HPV combined with TCT detection can reduce the misdiagnosis rate and improve the diagnostic accuracy rate, indicating that this method is of great value in the cervical cancer screening. Key words: Human papillomavirus; Thinprep cytology test; Cervical diseases