Analysis on the Results of 8463 Cases in Cervical Cancer Screening

Abstract

Objective To evaluate the clinical application of different approaches in cervical cancer screening. Methods From January 2007 to December 2010, a total of 8463 women who received cervical the cancer screening at First Affiliated Hospital of Jinan University according to three-step technique were recruited into this study. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of the First Affiliated Hospital of Jinan University. Informed consent was obtained from all participants. Results The positive rate of ≥ atypical squamous cells of undetermined significance (ASCUS) was 3.06% (259/8463), and≥ high-grade intraepithelial lesion (HSIL) was 0.67% (57/8463) in the results of Thin-prep cytologic test(TCT) of 8463 participants. The rate of human papilloma virus(HPV) infection was 32.17% (444/1380) with 1380 participants received genital human papilloma viral detection, included high-risk human papilloma virus(HR-HPV) was 27.32% (377/1380) and low-risk human papilloma virus (LR-HPV) 4.86%(67/1380). The positive rate of the most common genotypes HPV-16, -58, -52, -53 and -33 were 33.16% (125/377),21.22% (80/377),20.16% (76/377), 10.61 % (40/377) and 9.55% (36/377), respectively. 760 participants received colposcopy and the positive rate was 42.50% (323/760), while 371 biopsy specimens were obtained. The normal cervix pathological examination was 10.24% (38/371), chronic cervicitis and metaplasia of squamous epithelium was 34.77% (129/371), cervical intraepithelial neoplasia (CIN) I was 21.02% (78/371),CINⅡ was 13.48% (50/371), CINⅢ was 14.82% (55/371) and cervical cancer was 5.66% (21/371). The positive rate of cervical cancer, precancer and high-grade cervical intraepithelial neoplasia were 44.20% (164/371) and 31.54% (117/371) respectively. Conclusion The cytologic test, genital human papilloma virus detection, colposcopy and biopsies are suitable approach for cervical cancer screening according to three-step technique, and should establish individual project. Key words: cervical cancer screening; Thin-prep cytologic test (TCT); human papilloma virus (HPV); genotypes; colposcopy