Application of extracorporeal extended field radiotherapy in locally advanced cervical cancer

Abstract

Objective To investigate the application value of extracorporeal extended field radiotherapy in locally advanced cervical cancer. Methods A total of one hundred and twenty patients with stage IIB-IVA cervical cancer in the First Affiliated Hospital of Hebei North University from June 2012 to June 2014 were randomly divided into two groups: the control group and the observation group, each with 60 cases.The routine concurrent chemoradiotherapy was adopted in the control group.The observation group was treated with extracorporeal extended field radiotherapy combined with concurrent chemotherapy.The patients have been followed up for three years.The total efficacy rate, toxicity reaction, local progression free survival time (PFS) and survival rate of the two groups were compared. Results The total efficacy rate in the observation group was significantly higher than that of the control group (88.3%(53/60) vs.73.3%(44/60), χ2=4.357, P=0.037), while the incidences of toxicity reaction in the two groups were 18.3%(11/60) and 16.7%(10/60), the difference was not statistically significant (χ2=0.058, P=0.810), the percentages of I and II degree in the two groups were 3.4%(2/60) and 3.4%(2/60), the difference between the two groups was not statistically significant (Z=0.000, P=1.000). The PFS value in the observation group was significantly longer than that of the control group (25.6 months vs.13.8 months, χ2=25.624, P=0.000), and the survival rate in the observation group improved significantly (53.3%(32/60) vs.33.3%(20/60), the difference was statistically significant (χ2=4.887, P=0.027). Conclusion Extracorporeal extended field radiotherapy is safe and effective in the treatment of locally advanced cervical cancer. Key words: Extracorporeal extended field radiotherapy; Advanced cervical cancer; Efficacy rate; Toxicity reaction; Progression free survival; Survival rate