Abstract
Objective To investigate the effect of enteral nutrition support via naso-jejunal tube in esophageal carcinoma patients treated with radiotheraphy. Methods 36 esophageal carcinoma patients were randomly assigned into enteral nutrition(EN) group, while 38 patients assigned to control group.All patients underwent definition IMRT combined with weekly concurrent chemotherapy of paclitaxel-nedaplatin.The naso-jejunal tubes were bedside inserted by hand in EN group.Enteral nutrition support began the day after the tube insertion.The control group took food orally.Nutrition was assessed through body weight, BMI, lymphocyte, albumin, pre-albumin and hemoglobin.Treatment induced complications were recorded. Results The degree of nutritional reduction was lower in EN group and significantly different with the control group.The EN group underwent (4.5±1.1)cycles concurrent chemotherapy, the control group underwent (3.1±2.3)cycles concurrent chemotherapy(t=6.21, P=0.027). The hematotoxicity induced by chemoradiotherapy(CRT) was statistically severe in the control group(χ2=24.64, P<0.01), while radiation esophagitis was similar between the two groups. Conclusion EN support via naso-jejunal tube in esophageal carcinoma patients treated with radiotheraphy may improve the nutritional status, alleviate CRT induced hematotoxicity, increase tolerance of CRT. Key words: Esophageal neoplasms; Enteral nutrition
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