Abstract
Summary Observations have been recorded concerning the effects of various procedures such as removal of vagus innervation, transplantation of the antrum to the abdominal wall and into the colon, on the total output of gastric juice from a Pavlov pouch. It is concluded that the hormonal or antrum phase of gastric secretion is most important, the nervous phase of secretion is somewhat less, and the intestinal phase is least important in provoking the secretion of gastric juice from a Pavlov accessory stomach pouch. The antrum of the stomach, transplanted into the colon, causes a greater secretion of gastric juice than is produced when the antrum is in its normal location. This secretion may continue even though the original blood supply to the antrum is divided, and it is nourished by newly formed blood vessels from the colon. In the absence of other factors, the development of pressure within the isolated colon containing an antrum transplant as a result of peristalsis is a profound stimulation for antrum function. The significance of this finding as a possible explanation for the increase in gastric secretion accompanying pyloric stenosis in man is suggested.
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