Abstract
d-Nicotine (1000 μg) applied into the cerebral ventricle of urethane anesthetized rats increased gastric acid secretion. When 50 μg of d-nicotine was concomitantly administered with 5 μg of I-nicotine, the I-nicotine-induced increases in gastric secretion was blocked. The appearance of convulsion induced by I-nicotine in mice was also inhibited by pretreatment with d-nicotine. These results suggest that d-nicotine has agonistic and antagonistic actions to I-nicotine in the central nervous system and that its agonistic potency varies with preparations.
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