Antiulcer protective activity of gum Arabic (Acacia Senegal) in adult rats

Abstract

Arabic Gum (AG) is an edible, and has a complex chemical composition. In folk medicine, AG has been reported to be used internally for the treatment of inflammation of the intestinal mucosa, and externally to cover inflamed surfaces. It has been claimed to act as an antioxidant. The objective of this study were assessed the protective activity of Arabic gum on against peptic ulcer which induced by ethyl alcohol in adult male rats and its application in bakery product. Forty rats were randomly divided into five groups (n=8 for each), the first and second groups fed standard diet, the third, fourth and fifth groups fed standard diet containing 2.5, 5, 10% Arabic gum powder (AGP) respectively. At the last day of experimental period (28th day), the rats were fasted for 24 h with free access to water. The rats of second, third, fourth and fifth groups were received a single orally dose of ethyl alcohol 90% at 10 ml/kg body weight. After one hour later and under anesthesia by diethyl ether, abdominal wall was opened, the pylorus identified, stomachs ligated from esophageal opening, removed, opened at greater curvature, gastric juice collected and centrifuged for studying of gastric secretion parameters. Also, AGP was used to replace part of the whole wheat flour (0%, 2.5%, 5% and 10%) in standard bread. Appearance, taste, flavor, texture, , color and overall acceptability were evaluated in bread. The results showed that groups which treatment with AGP was significantly decreased in ulcer score, ulcer index and increase in preventive index compared with the positive control group. Supplemented rats diet with 10% of AGP was more effective to protect the stomach of ulcer. Moreover sensory evaluation showed that all replacement of GAP in bread was showed acceptable by the panelists. It conclude that Arabic gum had a protective activity against peptic ulcer in adult rats which induced by ethyl alcohol.