التأثيرات الوقائية المحتملة لنبات الخرشوف علي قرحة المعدة لدي الفئران

Abstract

: Artichoke has been reported to be used internally for the treatment of inflammation of the intestinal mucosa. It has been claimed to act as an antioxidant. The objective of this study was added artichoke powder in baked products and its assessed the protective activity of artichoke against peptic ulcer which induced by ethyl alcohol in adult male rats. Artichoke was used to replace part of the whole wheat flour ( 2.5%, 5% and 10%) in standard cake. Appearance, taste, flavor, texture, color and overall acceptability were evaluated in cake .The results showed that groups which treatment with artichoke were significantly decreased in ulcer score, ulcer index and increase in preventive index compared with the positive control group. Supplemented rats diet with 10% of artichoke powder were more effective to protect the stomach of ulcer. Moreover sensory evaluation showed that all replacement of artichoke in cake were showed acceptable by the panelists. It concluded that artichoke had a protective activity against peptic ulcer in adult rats which induced by ethyl alcohol. Also, Thirty rats were randomly divided into five groups (n=6 for each), the first and second groups fed standard diet, from the third to the fifth groups fed standard diet containing 2.5, 5, 10% artichoke powder(AP). The rats of second to fifth groups were received a single orally dose of ethyl alcohol 90% at 10 ml/kg body weight. After two hour later and under anesthesia by diethyl ether, abdominal wall was opened, the pylorus identified, stomachs ligated from esophageal opening, removed, opened at greater curvature, gastric juice collected and centrifuged for studying of gastric secretion parameters.