Abstract
BackgroundPeptic ulcer is the term which refers to acid peptic injury of the digestive tract, and it results in mucosal break reaching the submucosa. Leaves of Capparis zeylanica are used as counterirritant, rubefacient, as a cataplasm in piles, boils and swellings. The objective of the present study was to evaluate the antiulcer activity of C. zeylanica ethanolic extract against chemically induced ulcers. The leaves were extracted with ethanol (50%) as solvent using hot perforation method. The extract was evaluated against acute and chronic ulcer models. Further, extract was evaluated for gastric autopsy of animals infected with Helicobacter pylori bacteria. The genes of rats were evaluated by gel electrophoresis method. Morphology of stomach was also studied after treatment with plant extract.ResultsResults exhibited that the area of ulcer was significantly reduced in both acute [naproxen-induced ulcer model (3.62 mm2), histamine-induced ulcer model (3.2 mm2) and ethanol-induced ulcer model (106.4 mm2)] and chronic [chronic naproxen-induced ulcer model (2.14 mm2), chronic histamine-induced ulcer model (0.16 mm2)]. The animals of naproxen-induced ulcer infected with H. pylori showed 91.48% reduction of ulcer area on 9th week after treatment with C. zeylanica extract (360 mg/kg). The rapid urease test and DNA observation revealed that no infection was present from 4th week after treatment with C. zeylanica extract (480 mg/kg). Morphological studies showed less conspicuous petechial marks and hemorrhages in stomach tissues after treatment with test drugs. Histopathological study revealed that C. zeylanica extract reduced stomach damages and eradicated H. pylori infections.ConclusionIt can be concluded from the study that C. zeylanica possess antiulcer and anti-helicobacter activities.
Highlights
Peptic ulcer is the term which refers to acid peptic injury of the digestive tract, and it results in mucosal break reaching the submucosa [1]
The results indicated that C. zeylanica extract (120 mg/kg/day p.o.) had significant ulcers healing activity (Table 4)
The present study suggests that the C. zeylanica extract possesses potent antiulcer activity against chemicalsinduced ulcer with significant antimicrobial activity
Summary
Peptic ulcer is the term which refers to acid peptic injury of the digestive tract, and it results in mucosal break reaching the submucosa. The objective of the present study was to evaluate the antiulcer activity of C. zeylanica ethanolic extract against chemically induced ulcers. Extract was evaluated for gastric autopsy of animals infected with Helicobacter pylori bacteria. Morphology of stomach was studied after treatment with plant extract. Peptic ulcer treatment involves using a number of chemically produced drugs with aim to reduce the rate of stomach acid secretion, protection of the mucosa that. The herbal drugs are less toxic than synthetic drugs; the toxicity evaluation is required to determine the safety profile of herbal drug [19,20,21,22,23] In this concern, the drugs of natural origin can be used for the management of gastric ulcers as a better alternative to synthetic drugs [24]
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