Abstract
ABSTRACT Objective: The objective of the present study was to evaluate antitumor potential of Drosera burmannii vahl by using Ehrlich\'s Ascites Carcinoma (EAC) tumor model in swiss albino mice. Materials and Method: The normal control, EAC control, standard (5FU) and the ethanol and aqueous extracts (250 and 500mg/kg each) of D. burmannii vahl + EAC (four groups) were given the respective treatments24 h after tumor cell inoculation,for14 days. After 14 days, the antitumor potential was evaluated by increase in body weight, % Increase in Life Span (%ILS), tumor cell count, Mean Survival Time (MST), Packed Cell Volume (PCV) and various hematological parameters. Once the animals were sacrificed, the vital organs were removed for histopathological and antioxidant activity studies. Result: Oral administration of crude extracts increased the %ILS, MST and decreased the peritoneal ascetic fluid content, body weight and PCV significantly (pEEDB250=AEDB500>AEDB 250 respectively.
Published Version
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