Antithrombotic effects of cilostazol combined with clopidogrel and aspirin in senile patients with cerebrovascular disease after PCI surgery

Abstract

Objective To analyze the antithrombotic effects of cilostazol combined with aspirin and clopidogrel in elderly patients with cerebrovascular disease after PCI. Methods 100 elderly patients with cerebrovascular diseases who treated with coronary artery interventional therapy (PCI) were randomly divided into the control group and the observation group according to the digital table, 50casess in each group.The two groups were given control of blood pressure, blood lipids, blood sugar, improve circulation and other conventional treatment.The control group was treated with aspirin combined with clopidogrel, the observation group was treated with cilostazol based on the treatment of control group.Before and after treatment for 1, 4 and 8 weeks, the platelet aggregation degree was detected by PL-11 automatic platelet analyzer.During 2 months of follow-up, the degree of platelet aggregation, the volume of platelets, the efficacy of treatment and the incidence of adverse reactions were compared. Results The platelet aggregation rate between the two groups had no statistically significant difference before treatment (t0=2.782, P>0.05). After treatment, the platelet aggregation rate of the two groups decreased significantly, but after treatment for 1, 4 and 8 weeks, the platelet aggregation rates of the observation group were significantly lower than those of the control group [(51.87±9.65)%, (40.85±10.24)%, (38.52±9.64)%; (69.25±8.41)%, (62.43±9.22)%, (58.46±10.18)%], the differences were statistically significant (t1=5.693, t4=4.846, t8=6.719, all P 0.05). After treatment, the platelet volume of the two groups decreased significantly (t1=1.656, t4=1.438, t8=2.189, all P 0.05). The effective rate of the observation group was 94.00%(47/50), which was significantly higher than that of the control group [82.00%(41/50)], the difference was statistically significant (χ2=4.683, P<0.05). The incidence rates of adverse reactions in the observation group and the control group were 10.00% (5/50) and 8.00% (4/50), respectively, there was no statistically significant difference between the two groups (χ2=1.947, P=0.136). Conclusion Cilostazol combined with clopidogrel and aspirin in the treatment of elderly patients with cerebrovascular disease after PCI can significantly reduce platelet aggregation rate, improve clinical curative effect, and has certain clinical value. Key words: Cerebrovascular disorders; Angioplasty; Aspirin; Clopidogrel; Antithrombotic effect; Cilostazol