Antioxidant and Synergistic Antidiabetic Activities of a Three-Plant Preparation Used in Cameroon Folk Medicine.

Bruno Moukette Moukette,Cacral Prosper Biapa Nya,Pauline Nanfack,Marcel Azabji Kenfack,Vicky Jocelyne Ama Moor,Francine Tankeu Nzufo,Constant Anatole Pieme,Jeanne Yonkeu Ngogang

doi:10.1155/2017/9501675

Bruno Moukette Moukette, Cacral Prosper Biapa Nya + Show 6 more

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https://doi.org/10.1155/2017/9501675

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Abstract

Introduction. Several plant preparations like a mixture of aqueous extracts of Spilanthes africana; Portulaca oleracea; and Sida rhombifolia are currently utilized in Foumban (West Cameroon) to manage diabetes. The aim of this study is to investigate the antidiabetic property of the aqueous mixture of three plant extracts (1 : 1 : 1) on streptozotocin induced diabetes rats. Methods. Diabetes was induced to rats by intraperitoneal (i.p.) injection of streptozotocin (STZ) at a dose of 50 mg/kg b.w. The diabetic rats received different dosages of the mixture of extracts for 21 days and glibenclamide 6.5 mg/kg b.w. as positive control. Results. The results showed that the mixture of extracts significantly (p < 0.05) decreased the level of the glycaemia, the total cholesterol, triglyceride, and LDL-cholesterol as well as MDA, AST, ALT, and creatinine levels. It also increased significantly the concentration of HDL-cholesterol, glutathione, and TAOS. A great reduction of the atherogenic indexes CT/HDL and LDL/HDL of the treated groups was observed. Each extract and the mixture demonstrated significant scavenging property on DPPH and OH radicals and present a good antioxidant property. Conclusion. The mixture of plant extracts has hypoglycemic, antioxidant, and hypolipidemic properties and can be used for the management of diabetes mellitus.

Highlights

Several plant preparations like a mixture of aqueous extracts of Spilanthes africana; Portulaca oleracea; and Sida rhombifolia are currently utilized in Foumban (West Cameroon) to manage diabetes
According the International Diabetes Federation (IFD), the world diabetic population in 2015 was estimated to be 415 million and the prevalence increased from 4.7% in 1980 to 8.5% in 2015 [2]
For the DPPH scavenging activity, the fifty percent inhibitory concentration (IC50) of the extract varied from 2.93 to 3.47 μg/mL depending on the extract with S. africana demonstrating the lower concentration

Summary

Introduction

Several plant preparations like a mixture of aqueous extracts of Spilanthes africana; Portulaca oleracea; and Sida rhombifolia are currently utilized in Foumban (West Cameroon) to manage diabetes. The aim of this study is to investigate the antidiabetic property of the aqueous mixture of three plant extracts (1 : 1 : 1) on streptozotocin induced diabetes rats. The results showed that the mixture of extracts significantly (p < 0.05) decreased the level of the glycaemia, the total cholesterol, triglyceride, and LDL-cholesterol as well as MDA, AST, ALT, and creatinine levels. It increased significantly the concentration of HDL-cholesterol, glutathione, and TAOS. The mixture of plant extracts has hypoglycemic, antioxidant, and hypolipidemic properties and can be used for the management of diabetes mellitus. Some of them were scientifically studied for hypoglycemic and antidiabetic activities [5, 6]

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