Abstract
The aim of the present study was to investigate a cytotoxic oxidative cell stress related and the antioxidant profile of kaempferol, quercetin, and isoquercitrin. The flavonol compounds were able to act as scavengers of superoxide anion (but not hydrogen peroxide), hypochlorous acid, chloramine and nitric oxide. Although flavonoids are widely described as antioxidants and this activity is generally related to beneficial effects on human health, here we show important cytotoxic actions of three well known flavonoids. They were able to promote hemolysis which one was exacerbated on the presence of hypochlorous acid but not by AAPH radical. Therefore, despite they expected scavenger action over free radicals an oxidants, these compounds could be very lesive to living organisms by acting over erythrocytes and maybe other cellular types.
Highlights
Some physiological processes of reactive oxygen species generation are important to organisms’ functions and defenses, like polymorphonuclear neutrophils activation by endogenous or exogenous stimuli
The neutrophil activation is followed by increased oxygen consumption and a reactive oxygen species (ROS) production cascade which generates, among others, free radical superoxide anion (O2-), hydrogen peroxide (H2O2) and hypochlorous acid (HOCl) [1]
Considering reactive oxygen species participation on several pathologic processes and the crescent use of natural products as therapeutic, this study was undertaken in order to assess the action profile of three well known flavonoids kaempferol, quercetin and isoquercitrin, as scavengers agents of reactive oxygen species and evaluate if through their antioxidant properties these compounds are able to protect red blood cells against oxidative stress
Summary
Some physiological processes of reactive oxygen species generation are important to organisms’ functions and defenses, like polymorphonuclear neutrophils activation by endogenous or exogenous stimuli. There is increasing interest in natural antioxidant products for use as medicines and food additives [7, 8]. Phytochemicals such as polyphenols and carotenoids are gaining importance because of their contribution to human health and their multiple biological effects such as antioxidant, antimutagenic, anticarcinogenic and cytoprotective activities [9]. Considering reactive oxygen species participation on several pathologic processes and the crescent use of natural products as therapeutic, this study was undertaken in order to assess the action profile of three well known flavonoids kaempferol, quercetin and isoquercitrin, as scavengers agents of reactive oxygen species and evaluate if through their antioxidant properties these compounds are able to protect red blood cells against oxidative stress
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