Antioxidant and antidiabetes activity from the fruit shell of Calophyllum inophyllum

Jamilah Abbas Abbas,Nina Artanti,Minarti Minarti

doi:10.14203/inajac.v23i2.508

Abstract

Antioxidant and antidiabetes activity from the fruit shell of Calophyllum inophyllum

Highlights

C. inophyllum is a large genus in Gutteferae family with about 180-200 species, which is distributed mainly in tropical forests such as China South and Southeast Asia, Eastern Africa, Madagascar, the Pacific island, America, Australia and Brazil
Based on the results of the TLC analysis, the fractions that gave the same results were combined, so that two sub-fractions were obtained, namely sub fraction 1 (SF1) and SF2. These two sub fractions were analyzed for the total phenolic content, total flavonoid content, antioxidant activity and antidiabetic activity
The phytochemical screening from n-hexane fraction of fruit shell C. inophyllum namely SF1 and SF2 showed that both contained higher total flavonoid contents compared to total phenolic content

Summary

Introduction

C. inophyllum is a large genus in Gutteferae family with about 180-200 species, which is distributed mainly in tropical forests such as China South and Southeast Asia, Eastern Africa, Madagascar, the Pacific island, America, Australia and Brazil. Calophyllum species are large hardwood and are generally grown in a mountain forest to coastal swamps. The genus Calophyllum has potential for timber and as folk medicines for various diseases such as vaginal discharge, rheumatism, scabies, ulcers, and hair grower [1,2]. In 2016, Li et al have successfully isolated four coumarins compounds i.e. Have analyzed proximate content : i.e. moisture, ash, protein, crude fiber, carbohydrate, mineral and identified 3 compounds i.e. trans-2[2(trifluoromethyl) phenyl]-10b, 10c-dimethyl-10b and 10c-dihydropyren from C.inophyllum leaves [3]. Dipyranocoumarin has been isolated from callus of C.inophyllum Lin, that pyranocoumarin have anti-HIV activity [4]. Qi Xu [5] proved that Calanolide A is active against both drugsusceptible and drug-resistant strains of Mycobacterium tuberculosis

Objectives

Methods

Findings

Conclusion