Abstract
Mulberry ( Morus alba L. ) is considered as an important plant in traditional Chinese medicine, due to its various compounds, including phenols and flavanoids, which have antioxidant properties so that it can be a potential anticancer candidate. This study aimed to determine the antioxidant activity, phenolic content, and potential anticancer activity in Mulberry stem extract. The extraction was done by maceration using ethanol as the solvent, while antioxidant activity test used ABTS (2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) method, phenolic content determination used Folin-Ciocalteu reagents, and anticancer activity test used the MTT (3-(4,5- dimetiltiazol-2-il)-2,5-difenil tetrazolium bromida) method on WiDr cancer cells and Vero cells. The result of total phenolic Mulberry stem extract was 35.9%, the antioxidant activity value was 83.18 µg/mL, the IC50 value for anticancer activity for WiDr cells was 71.24 µg/mL and Vero cells IC50 value was 154.241 µg/mL. It could be concluded that the Mulberry stem ethanol extract has strong antioxidant activity and has the potential to be an anticancer agent selectively against WiDr cancer cells.
Highlights
Cancer is one of the leading causes of death in the worldwide
One of the plants used by the community as medicine is Mulberry (Morus Alba L.) which has many potentials, including reduce blood cholesterol, antidiabetes, and antihypertension (Mallaleng et al, 2011)
Antioxidant compounds produced as vitamin C, vitamin E, carotene, groups of phenolic compoundsespecially polyphenols and flavonoids-are known to have the potential to reduce the risk of degenerative diseases (Kuntorini and Astuti, 2010)
Summary
Cancer is one of the leading causes of death in the worldwide. The number of cancer patients is predicted to increase each year. Cancer patients reach 23.6 million cases per year in 2030 (Ministry of Health RI, 2016). One of the plants used by the community as medicine is Mulberry (Morus Alba L.) which has many potentials, including reduce blood cholesterol, antidiabetes, and antihypertension (Mallaleng et al, 2011). The plants generally contain phenolic compounds such as flavanoids, synamic acid derivatives, coumarins, and tocopherols (Gupita and Rahayuni, 2012). Antioxidant compounds produced as vitamin C, vitamin E, carotene, groups of phenolic compoundsespecially polyphenols and flavonoids-are known to have the potential to reduce the risk of degenerative diseases (Kuntorini and Astuti, 2010)
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