Abstract
Plant products have been used as medicines against fungal infectious diseases. In this research antimycotic activity of the leaf extracts of five medicinal plants (Nerium indicum, Catheranthus roseus, Lantana camera, Ziziphus mauritiana) were tested against three dermatophytes (Trichophyton mentagrophytes, Trichophyton rubrum and Microsporum. gypseum). Development of more effective and less toxic antimycotic agents is required for the treatment of dermatophytosis. The plant materials were extracted with methanol, ethanol and diethyl ether solvent to investigate their antimycotic activities in Vitro. Ethanol and methanol extracts of all selected medicinal plants were showed the positive activity against all tested dermatophytes. Diethyl ether extract was showed lowest activity against T. mentagrophytes and T. rubrum and showed moderate activity against M. gypseum. The three dermatophytes differed with regard to their susceptibility to plant extracts.
Highlights
Plants have been considered a valuable source of natural products for maintaining human health
The leaves of four medicinal plants viz., Nerium indicum, Ziziphus mauritiana, Catheranthus roseus and Lantana camera were collected from spring and summer seasons in the local area of Ajmer district, Rajasthan
At present fungal infections have become an important clinical threat which is due to the development of fungal resistance to the existing antifungal agents
Summary
Plants have been considered a valuable source of natural products for maintaining human health. Plants have a long history of antibiotic usage for the cure of infectious disease, caused by pathogenic micro-organisms. Plant and their product have been used since ancient times for medicinal purpose. Much attention has been refocused on plant origin of antimicrobial and anti dermatophytic agents, after the discovery of penicillin. This is considered to be one of the most important life-saving Phyto-drugs. Medicinal plants represent a rich source of secondary metabolites, many of which possess antimicrobial properties. Screening of medicinal plants provides another alternative for producing chemical fungicides that are relatively non-toxic and cost-effective
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