Abstract
Dermatophytes are the most common slow growing contagious agents of cutaneous mycosis and persist as a significant public health issues despite of the availability of a number of antifungal medications. Trichophyton mentagrophytes is one of the fungal species which influences the dermatophytic diseases. A wide range of clinical dermatophytosis such as tinea barbae (beards), tinea captis (scalp), tinea corporis (ring worm of the body), tinea faciei (face), tinea manuum (hand), tinea inguinalis (jock itch), tineaunguium or onychomycosis (nail unit),paronychia (proximal and lateral folds of fingernails, toenails and tissue borders sides and root of nail), tinea pedis (feet) and tinea cruris (pubic region) could be produced by this pathogenic species depending on the affected parts. Generally, terbinafine, is used to treat dermatophytosis induced by Trichophyton species. In most of the cases, synthetic anti-mycotic drugs fail over time resulting in development of resistant strains. Sustainable use of herbal sources has been recognised as novel therapeutic drugs to treat dermatophytic disorders. However, few reports are available on antimycotic activity of lichen species. Therefore, in this study, lichen species such as Roccella montagnei Bel. was collected from prime locality of Bhubaneswar, Odisha. Antifungal potency of ethanol and methanol extractives of R. montagnei Bel. was screened by disc diffusion method against the clinical isolates of T. mentagrophytes. The overall study resulted with a positive output and validated through in-silico database. Hence the entire study is based on biomedical evaluation and sustainable use of natural plant supplements for the benefit of human society.
Published Version
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