Abstract
Nanobiotechnology has offered great attention in drug delivery and the development of various medicines used to treat microorganism infections. The present investigation deals with antimycobacterial activity, in-vitro hemolysis assay, and antioxidant activity of nickel oxide nanoparticles (NiO NPs). NiO NPs, with controlled size and shape, prepared by a simple and inexpensive successive ionic layer adsorption and reaction (SILAR) method was scanned using field emission scanning electron microscopy (FE-SEM) and high-resolution transmission electron microscopy (HR-TEM) digital images for surface morphology confirmation. Spherical irregular island-type NPs of about 24 nm diameter are obtained. The X-ray diffraction pattern demonstrates the synthesis of polycrystalline and cubic in phase NiO NPs. The Raman spectrum has revealed the presence of two vibration bands cantered at 550 and 1095 cm−1 for one photon longitudinal optical, and two longitudinal optical modes, respectively. The as-prepared NiO NPs endow 10 µg/mL against Mycobacterium tuberculosis (M. tuberculosis, MTCC-300) and 10 µg/mL against Mycobacterium phlei (M. phlei, MTCC-1723) inhibitory concentrations. The hemolytic activity of NiO NPs has also been explored. The antioxidant result demonstrates 63.44% for NiO NPs over 88.23% for standard, i.e., di(phenyl)-(2, 4, 6-trinitrophenyl) viminoazaniun antioxidant. Taken together, NiO NPs act as a potential candidate against mycobacteria.
Highlights
The flexible ability of material science and nanotechnology to arrange nanostructures of controlled size and shape is likely to lead to the expansion of new drugs [1]
We present on the synthesis of nickel oxide nanoparticles (NiO NPs) using a simple, eco-friendly, and cost-effective successive ionic layer adsorption and reaction (SILAR) chemical method
One cycle for the synthesis of nickel hydroxide on substrate surface was a combination of two half-cycles; the first half cycle was an immersion of vertical plunging of the cleaned glass substrate into the freshly prepared 0.1 M NiCl2 ·6H2 O as a source of nickel wherein ammonia solution was added for pH ≈ 12, so that nickel species (Ni2+ ) can adsorb on the glass substrate
Summary
The flexible ability of material science and nanotechnology to arrange nanostructures of controlled size and shape is likely to lead to the expansion of new drugs [1]. The physicochemical properties of NPs can be tuned through dropping or varying sizes, mostly when the manipulations are done at the atomic level. This enables us to use nano-sized metals and metal oxides of zinc, Coatings 2020, 10, 1242; doi:10.3390/coatings10121242 www.mdpi.com/journal/coatings. Coatings 2020, 10, 1242 silver, copper, nickel, gold, cobalt, iron titanium and iron, etc., in biomedical applications. The bactericidal activity of these materials is mainly depending on their concentration in the growth/synthesis medium [5]. Versatile nickel oxide (NiO) has been envisaged in gas sensing [6], photovoltaic [7], catalysis activity [8], light-emitting diode [9], and supercapacitor [10], etc., applications
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