Abstract
(-)-Untenospongin B isolated from the marine sponge Hippospongia communis has been tested for its antimicrobial activity against bacteria and human pathogenic fungi using agar disk method and was found to possess a broad and strong activity toward the test organisms. Its antifungal activity was further characterized by determination of the minimum inhibitory concentration (MIC) against five fungal species using broth microdilution method.
Highlights
Incidence of fungal infection is emerging worldwide and despite treatment, mortality remains high [1]
The results of its antibacterial and antifungal activity are summarized in Table 1. (-)-Untenospongin B has shown a broad antimicrobial activity exhibiting antibacterial activity against Escherichia coli, Bacillus subtilis as well as against the ichthyopathogenic strain Vibrio anguillarum. (-)-Untenospongin B showed an in vitro antifungal activity against Candida albicans, Aspergillus fumigatus, and some other fungi
The results showed that the test medium had a significant influence on the minimum inhibitory concentration (MIC) values
Summary
Incidence of fungal infection is emerging worldwide and despite treatment, mortality remains high [1]. With the emergence of new triazol-resistant strains of fungi, new compounds must still be screened in search of fungicidal effect with a broad spectrum of activity and without side effects. Sponges (Porifera) are one of the richest sources of both biologically active secondary metabolites and chemical diversity [5, 6]. These natural products may play a role in warding off predators, and perhaps they repel fouling organisms. It is worth noting that (-)untenospongin B is very closely related to another sponge metabolite (+)-tetrahydrofurospongin-1 whose stereochemistry has been well established
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